Scott Speedman
Tony Curran
Derek Jacobi
Bill Nighy
Lily Mo Sheen
Shane Brolly
Michael Sheen
Zita Görög
Steven Mackintosh
Sophia Myles
John Mann

- Kate Beckinsale's chair had, instead of her name, "My Sweetie" on it surrounded by tiny hearts.
- Had a 71-day shooting schedule.
- The name Michael Corvin (Scott Speedman) was originally the intended name for the main character in The Crow: City of Angels (1996), which was changed to the name Ashe Corven.
- While filming a scene where Selene and Michael look at each other longingly, director Len Wiseman surprised the cast and crew by playing Bryan Adams' song "Everything I Do (I Do It For You)", at which everyone started laughing.
- The little girl that plays young Selene is Lily Mo Sheen, the daughter of Kate Beckinsale and Michael Sheen.
- Actress Kate Beckinsale wanted to use movies like Aliens (1986) and The Terminator (1984) as the basis for her role as an action heroine, but when they first talked about the movie, director/husband Len Wiseman suggested that she check out Russell Crowe in L.A. Confidential (1997) instead.

- Selene: Well, we'll have to work on that.
- Selene: Yes!
- Selene: You know what Marcus will do! If he finds me, he finds William's prison! You have to help us stop him!
- Selene: Everything I've done can be laid at YOUR feet - hundreds of thousands have died because of your inability to accept that your sons are monsters, that they CREATE monsters!
- Selene: [glances at Michael] We're not leaving him here.
- Selene: You're Alexander Corvinus...
- Selene: What will I become?
- Selene: [to Michael] There's never been a hybrid before. However ambivalent you might feel about it, the truth is, your powers could be limitless. You depend on blood.
- Selene: [picks up the abandoned bra of one of Tanis's girlfriends] Your exile seems a bit more comfortable than I remember.
- Selene: Viktor deserved his fate. And Kraven was no better.
- Selene: For six centuries I was a loyal soldier to the vampire clan. But I was betrayed. The war was not as it had seemed. In one night, the lies that had united our kind had been exposed. Kraven, our second-in-command, had formed a secret alliance with Lucian, leader of the werewolf clan, to overthrow Viktor, our leader. But Kraven's lust for power and domination had failed. Viktor was not the savior I had been led to believe. He had betrayed us all. Soon, the hunt will be on for his killer. I have but one ally left: Michael, the human descendent of Corvinus. Neither vampire nor lycan, but a hybrid. It's only a matter of time before we're found. My only hope now is to awaken Markus, our last remaining elder, and expose the truth before Kraven tries to murder him while he's still in hibernation. Kraven knows he's no match for him awake.

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