Hugh Jackman
Richard Roxburgh
David Wenham
Elena Anaya
Will Kemp
Shuler Hensley
Silvia Colloca
Josie Maran
Kevin J. O'Connor

- During filming, Hugh Jackman accidentally broke an extra's hand.
- In this movie, Kate Beckinsale plays a vampire hunter. In Underworld (2003) and Underworld: Evolution (2006) she plays a vampire.
- While preparing for the ballroom scene, Stephen Somers had Richard Roxburgh, Kate Beckinsale and Elena Anaya practice dancing for hours every day so their performance would be flawless.
- Dracula's diminutive henchmen, the Dwerger, are actually dwarfs from Germanic folklore.
- The place where Van Helsing and Anna fight Dracula's three wives is the same place where they filmed Frankenstein (1931), Dracula (1931/I) and The Wolf Man (1941). The place is call the Court of Miracles and this place is also found at the studio tour at Universal Studios Hollywood.
- The Transylvanian town built for this movie is to be the basis for a TV series. According to the producers, it was too good to just tear down.
- Stephen Sommers wanted Kate Beckinsale for the role of Anna, but feared it was too similar in tone to the vampire/werewolf film _Underworld (2003/I)_ which she was shooting at the time, and he didn't ask her. Eventually her agent got Sommers to send the script and Beckinsale immediately signed on.
- There are three separate scenes where a werewolf falls off something and into a body of water, making a small but noticeable splash. This is an in-joke on Wile E. Coyote.
- Kate Beckinsale was the last to be cast.
- The dialogue in the scene where Anna drives a stake through Aleera and tells her "if you're going to kill someone kill them don't stand there taking about it" is almost identical to that of the scene in Buono, il brutto, il cattivo., Il (1966), where after shooting the bounty hunter, Tuco tells him "if you're going to shoot someone, shoot them don't talk about it".

- Anna Valerious: He's the first one to kill a vampire in over a hundred years. I'd say that's earned him a drink.
- Anna Valerious: I think if you're going to kill somebody, kill them! Don't stand around talking about it!
- Anna Valerious: For me this is all personal. It's all about family and honor. Why do you do it? What do you hope to get out of it?
- Anna Valerious: And what have you got out of it so far?
- Anna Valerious: A silver stake? A crucifix? What, did you think we haven't tried everything before? We've shot him, stabbed him, clubbed him, sprayed him with holy water, staked him through the heart, and STILL he lives! Do you understand? No-one knows how to kill Dracula!
- Anna Valerious: We Transylvanians always look on the brighter side of death.
- Anna Valerious: Of course. It's just harder to see.
- Anna Valerious: Dwergi!
- Anna Valerious: Dracula's servants. Industrious, but extremely vicious. If you get a chance to kill one, do it, because they'll do worse to you.
- Anna Valerious: Oh, my God! The Frankenstein Monster!
- Anna Valerious: Some say you're a murderer, Mr. Van Helsing. Others say you're a holy man. Which is it?
- Anna Valerious: Through that window!
- Anna Valerious: What do you want?
- Anna Valerious: How do you know he has copper teeth?
- Anna Valerious: I'll clip off something.
- Anna Valerious: [while looking at the cure for the werewolf curse] Go ahead, grab it.
- Anna Valerious: You knew?
- Anna Valerious: Before or after I stopped you from shooting him?
- Anna Valerious: And still you tried to kill him!
- Anna Valerious: It's not his fault! He can't help it!
- Anna Valerious: [after Van Helsing has killed the Werewolf] You killed him!
- Anna Valerious: You make my skin crawl.
- Anna Valerious: And kill anyone who gets in our way.
- Anna Valerious: Then we've lost.
- Anna Valerious: "Time"? The sun sets in two hours, and we've been searching for his lair for over 400 years!
- Anna Valerious: You! Turn around. Let me see your faces.
- Anna Valerious: Because we don't trust strangers.
- Anna Valerious: I hope you have a heart, Aleera, because someday I'm going to drive a stake through it.
- Anna Valerious: What are these things?
- Anna Valerious: His children?
- Anna Valerious: Don't let it touch your tongue... it'll knock straight on your aaaaaa...

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